Lymphoid Enhancer Factor-1 Blocks APC-mediated Nuclear Export and Degradation of β-catenin: Regulation by Histone Deacetylase 1
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Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus.
Wnt signaling, via the activation of the canonical beta-catenin and lymphoid enhancer factor (LEF)/T-cell factor pathway, plays an important role in embryogenesis and cancer development by regulating the expression of genes involved in cell proliferation, differentiation, and survival. Dapper (Dpr), as a Dishevelled interactor, has been suggested to modulate Wnt signaling by promoting Dishevell...
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RATIONALE Myocyte enhancer factor 2 (MEF2) transcription factors drive the genetic reprogramming that precipitates pathological cardiac hypertrophy and remodeling. Class II histone deacetylase (HDAC) isoforms, such as HDAC5, act as signal-responsive repressors of MEF2 activity in cardiac myocytes and their nuclear export provides a key mechanism for the neurohormonal induction of such activity....
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β-Catenin transduces the Wnt signaling pathway and its nuclear accumulation leads to gene transactivation and cancer. Rac1 GTPase is known to stimulate β-catenin-dependent transcription of Wnt target genes and we confirmed this activity. Here we tested the recent hypothesis that Rac1 augments Wnt signaling by enhancing β-catenin nuclear import; however, we found that silencing/inhibition or up-...
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beta-Catenin is a protein that plays a role in intercellular adhesion as well as in the regulation of gene expression. The latter role of beta-catenin is associated with its oncogenic properties due to the loss of expression or inactivation of the tumor suppressor adenomatous polyposis coli (APC) or mutations in beta-catenin itself. We now demonstrate that another tumor suppressor, PTEN, is als...
متن کاملCRM1- and Ran-independent nuclear export of β-catenin
Background: Activation of the Wnt pathway induces -catenin to localize Address: Max-Planck-Institute for Developmental Biology, Department of Cell Biology, Tübingen inside the nucleus, where it interacts with transcription factors such as D-72076, Germany. TCF/LEF-1. Regulation of the pathway occurs through a -catenin– degrading complex based on Axin and the tumor suppressor APC. We have Corres...
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تاریخ انتشار 2002